한빛사논문
- 조회921
Nicholas R. Colaianni1,2,3,6, KatarzynaParys4,6,7, Ho-Seok Lee4,6, Jonathan M. Conway1,3, Nak Hyun Kim1,3, Natalie Edelbacher4, Tatiana S. Mucyn1,3, Mathias Madalinski4, Theresa F. Law1,3, Corbin D. Jones1,2,5,*, Youssef Belkhadir4,*, Jeffery L. Dangl1,2,3,8,*
1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
2Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
3Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
4Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, Vienna, Austria
5Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
6These authors contributed equally
7Present address: Faculty of Biology, Genetics, University of Munich (LMU), 82152 Martinsried, Germany
8Lead contact
*Corresponding author
Abstract
Immune systems restrict microbial pathogens by identifying “non-self” molecules called microbe-associated molecular patterns (MAMPs). It is unclear how immune responses are tuned to or by MAMP diversity present in commensal microbiota. We systematically studied the variability of commensal peptide derivatives of flagellin (flg22), a MAMP detected by plants. We define substantial functional diversity. Most flg22 peptides evade recognition, while others contribute to evasion by manipulating immunity through antagonism and signal modulation. We establish a paradigm of signal integration, wherein the sequential signaling outputs of the flagellin receptor are separable and allow for reprogramming by commensal-derived flg22 epitope variants. Plant-associated communities are enriched for immune evading flg22 epitopes, but upon physiological stress that represses the immune system, immune-activating flg22 epitopes become enriched. The existence of immune-manipulating epitopes suggests that they evolved to either communicate or utilize the immune system for host colonization and thus can influence commensal microbiota community composition.
Keywords : plant immunity, flagellin, host-microbe interactions, pattern recognition receptors, ligand-receptor interactions, bacterial evolution, receptor antagonism, Ralstonia, plant microbiome, community formation
논문정보
- Research article
- 2021년 03월 (BRIC 등록일 2021-03-22)
- 국외 연구진
- 생명과학 > 식물학
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