한빛사논문
- 조회6,483
Abstract
The costimulatory molecule 4-1BB and its ligand 4-1BBL can control adaptive immunity, but here we show that their interaction also suppressed myelopoiesis. We found that 4-1BBL was expressed on hematopoietic stem cells, differentiating common myeloid progenitors and granulocyte-macrophage progenitors, and 4-1BB was inducible on activated myeloid progenitors. Steady-state numbers of granulocyte-macrophage progenitors, myeloid-lineage cells and mature dendritic cells were higher in 4-1BB- and 4-1BBL-deficient mice, indicative of a negative function, and we confirmed that result with bone marrow chimeras and in vitro, where the absence of interactions between 4-1BB and 4-1BBL led to enhanced differentiation into dendritic cell lineages. The regulatory activity was mediated by 4-1BBL, with binding by 4-1BB inhibiting differentiation of myeloid progenitors. Thus, 4-1BB and 4-1BBL have a previously unknown function in limiting myelopoiesis and the development of dendritic cells.
1. Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology,
San Diego, California 92121, USA
2. Division of Developmental Immunology,
La Jolla Institute for Allergy and Immunology, San Diego, California 92121,
USA.
3. Immunomodulation Research Center, University of Ulsan, Ulsan, Korea,
and National Cancer Center, Goyang, Kyonggi-do, Korea.
4. Department of Surgery
and Emory Vaccine Center, University School of Medicine, Emory University, Atlanta,
Georgia 30329, USA.
5. Present address: Cell and Immunobiology, and R&D
Center for Cancer Therapeutics, National Cancer Center, Ilsan, Gyeonggi-Do,
Korea.
Correspondence to: Michael Croft1
논문정보
- Research article
- 2008년 07월 (BRIC 등록일 )
- 국내+국외 연구진
- 생명과학 > 면역학
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