한빛사논문
- 조회1,254
Sung-Bin Parka, Moon-Hee Sungb, Hiroshi Uyamac, Dong Keun Hana,*
aDepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea
bDepartment of Bio and Fermentation Convergence Technology, BK21 PLUS Project, Kookmin University, Seoul 02707, Republic of Korea
cDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita 565-0871, Japan
*Corresponding author.
Abstract
Numerous biopolymer-based functional composites have been developed for medical applications. Poly(glutamic acid) (PGA) is an amino acid biopolymer that has recently attracted attention due to its biocompatibility, non-immunogenicity, and biodegradability. PGA and its composites have been studied to improve their function as medical materials. This review briefly introduces chemically and microbiologically synthesized PGA. In addition, this article provides general and advanced preparation methods for various PGA-based composites, including hydrogels, nanofibers, monoliths, and nanoparticles. Furthermore, it covers recent advances in PGA-based functional composites for medical applications, such as active antimicrobial materials as well as the use of PGA composites for vaccine adjuvants, cancer therapy, medical devices, and tissue regeneration. Anticancer agent delivery and cancer immunotherapy are included in the PGA-based cancer therapy system section. Barrier membranes and stent applications are summarized within the medical devices section. Furthermore, various tissue regeneration topics are introduced, including applications in wound healing, as well as the tissue-specific regeneration of bone, cartilage, intervertebral discs, corneas, kidneys, and neurons. In summary, this is an overview of the various challenges of using PGA and the scope of emerging research.
논문정보
- Review Paper
- 2021년 02월 (BRIC 등록일 2021-02-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
