한빛사논문
- 조회892
Woo Seok Kim1, Sungcheol Hong1, Milenka Gamero1, Vivekanand Jeevakumar2, Clay M. Smithhart2, Theodore J. Price2, Richard D. Palmiter3,*, Carlos Campos4,* & Sung Il Park1,5,*
1Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA. 2School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA. 3Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. 4Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA. 5Institute for Neuroscience, Texas A&M University, College Station, TX, USA.
*Corresponding author
Abstract
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.
논문정보
- Research article
- 2021년 01월 (BRIC 등록일 2021-01-18)
- 국외 연구진
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