한빛사논문
- 조회1,148
Seon Joo Parka,1, Sung Eun Seoa,b,1, Kyung Ho Kima, Sang Hun Leef, Jinyeong Kima, Siyoung Haa, Hyun Seok Songe,*, Seung Hwan Leed,*, Oh Seok Kwona,c,*
aInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea
bDepartment of Civil and Environmental Engineering, Yonsei University, Seoul, 03722, South Korea
cNanobiotechnology and Bioinformatics (Major), University of Science & Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea
dDepartment of Bionano Engineering, Hanyang University, Ansan, 15588, Republic of Korea
eSensor System Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea
fDepartment of Chemical and Biological Engineering, Hanbat National University, Daejeon, 34158, South Korea
1These authors contributed equally to this work.
*Corresponding author
Abstract
In this paper, we propose a novel field-effect transistor (FET) using graphene, which is a two-dimensional (2D) nanomaterial, capable of evaluating water quality, and immobilizing the surface of a graphene micropatterned transistor with a highly responsive bioprobe for a water contamination indicator, geosmin, with high selectivity. A high-quality bioprobe-immobilized graphene FET (GFET) was fabricated for the real-time monitoring of geosmin using a liquid-gate measurement configuration. Immobilization was confirmed by measuring the change in the electrical characteristics of the platform (slope of the current-voltage (I–V) curve) and fluorescence images. In addition, a selectivity test showed remarkable implementation of the highly sensitive sensing platform with an insignificant signal when a nontarget was added. Using the fabricated device, the linear range for geosmin detection was determined to be from 0.01 nM - 1 μM with a detection limit of 0.01 nM. In addition, geosmin concentrations as low as 10 nM could be determined from river water samples with the sensor platform. This sensor can be utilized to immediately determine the presence of odorous substances by analyzing a water supply source without additional pretreatment. Another advantage is that the sensor device is a promising tool that does not have special equipment that requirs careful maintenance. In addition, the device provides a new platform for detecting harmful substances in various water sources by varying the bioprobes that are empolyed.
Keywords : Graphene field-effect transistor, Portable nanobiosensor, Geosmin, Odor compound, Real-time monitoring
논문정보
- Research article
- 2021년 02월 (BRIC 등록일 2021-01-25)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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