한빛사논문
- 조회1,180
Sung Min Yang1, Katrin Michel2, Vahbiz Jokhi1, Elly Nedivi2,3,4,*, Paola Arlotta1,5,*
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
2Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
*Corresponding author.
Abstract
Myelin plasticity is critical for neurological function, including learning and memory. However, it is unknown whether this plasticity reflects uniform changes across all neuronal subtypes, or whether myelin dynamics vary between neuronal classes to enable fine-tuning of adaptive circuit responses. We performed in vivo two-photon imaging of myelin sheaths along single axons of excitatory callosal neurons and inhibitory parvalbumin-expressing interneurons in adult mouse visual cortex. We found that both neuron types show homeostatic myelin remodeling under normal vision. However, monocular deprivation results in adaptive myelin remodeling only in parvalbumin-expressing interneurons. An initial increase in elongation of myelin segments is followed by contraction of a separate cohort of segments. This data indicates that distinct classes of neurons individualize remodeling of their myelination profiles to diversify circuit tuning in response to sensory experience.
논문정보
- Research article
- 2020년 12월 (BRIC 등록일 2021-01-11)
- 국외 연구진
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