한빛사논문
- 조회568
Bo Kyeong Yoona, Won-Yong Jeona, Tun Naw Suta,b, Nam-Joon Chob,* and Joshua A. Jackmana,*
aSchool of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea
bSchool of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore
*Corresponding Authors
Abstract
Membrane-enveloped viruses are a leading cause of viral epidemics, and there is an outstanding need to develop broad-spectrum antiviral strategies to treat and prevent enveloped virus infections. In this review, we critically discuss why the lipid membrane surrounding enveloped virus particles is a promising antiviral target and cover the latest progress in nanotechnology research to design and evaluate membrane-targeting virus inhibition strategies. These efforts span diverse topics such as nanomaterials, self-assembly, biosensors, nanomedicine, drug delivery, and medical devices and have excellent potential to support the development of next-generation antiviral drug candidates and technologies. Application examples in the areas of human medicine and agricultural biosecurity are also presented. Looking forward, research in this direction is poised to strengthen capabilities for virus pandemic preparedness and demonstrates how nanotechnology strategies can help to solve global health challenges related to infectious diseases.
KEYWORDS: virus, enveloped virus, antiviral, lipid membrane, peptide, biosensors, drug delivery, nanomedicine, pandemic, biosecurity
논문정보
- Review Paper
- 2020년 12월 (BRIC 등록일 2021-01-07)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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