구.농수식품
- 조회793
Abstract
Inyoung Choia, DaSom Yoob, Yoonjee Changc, SoYeon Kimc,d,*, Jaejoon Hana,e,*
aDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea
bDepartment of Food and Nutrition, Kookmin University, Seoul 02707, Republic of Korea
cCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
dDivision of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea
eDepartment of Food Biosciences and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea
*Corresponding author
Abstract
Bacteriophages (phages) have been extensively utilized as antibacterial agents in the food industry because of their host-specificity. However, their application in polymer films has been limited because of the lack of a strong attachment method for phage to the surface. We developed an antibacterial film by covalently immobilizing Escherichia coli (E. coli)-specific phage T4 on a polycaprolactone (PCL) film. The chemical bond formation was confirmed by XPS analysis, and the covalent attachment of phage T4 effectively inhibited E. coli growth even after external stimulation of the film by sonication. When applied as a packaging film for raw beef inoculated with E. coli O157:H7, the chemically functionalized PCL film showed approximately 30-fold higher bacterial inhibitory effects than the film with physically adsorbed phage T4. These results indicate the promising application potential of chemically functionalized PCL film with phage T4 as an antibacterial food packaging material against the foodborne pathogen E. coli.
논문정보
- Research article
- 2020년 12월 (BRIC 등록일 2021-01-05)
- 국내 연구진
- 생명과학 > 식품학
- 구・농수식품
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