한빛사논문
- 조회525
Qingyang Liu1,2, Myung H. Kim3,*, Leon Friesen1,2 and Chang H. Kim1,2,4,†
1Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
2Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
3Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
4Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
†Corresponding author.
*Present address: Department of Animal Science, Pusan National University, Republic of Korea.
Abstract
Early hematopoietic progenitors undergo sophisticated developmental processes to become committed innate lymphoid cell (ILC) progenitors and ultimately mature ILC subsets in the periphery. Basic leucine zipper ATF-like transcription factor (Batf) plays important roles in lymphocyte biology. We report here that Batf regulates the production of bone marrow ILC progenitors and maintenance of peripheral ILCs. The expression of Batf is induced during ILC development at the α-lymphoid progenitor stage in response to the cytokine IL-7. As a potential mechanism, up-regulated Batf binds and activates transcription of the Nfil3 gene to promote ILC hematopoiesis. Batf is necessary to maintain normal numbers of early and late ILC progenitors in the bone marrow and mature ILC1, ILC2, ILC3, and NK cells in most peripheral tissues. Batf deficiency causes ILC lymphopenia, leading to defective ILC responses to inflammatory cytokines and defective immunity to enteric bacterial infections. Thus, Batf plays critical roles in bone marrow hematopoiesis, peripheral homeostasis, and effector functions of ILCs.
논문정보
- Research article
- 2020년 12월 (BRIC 등록일 2020-12-29)
- 국외 연구진
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