한빛사논문
- 조회601
Adrian Kwan Ho Loe1,2,3, Abilasha Rao-Bhatia1,2,3, Ji-Eun Kim1,2,3, Tae-Hee Kim1,2,*
1Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Equal contributions
*Correspondence
Abstract
Mesenchymal-epithelial crosstalk plays a crucial role in organ development and stem cell function. However, the identity of the mesenchymal cells involved in this exchange was unclear. Recent significant advances in single-cell transcriptomics have defined the heterogeneity of these mesenchymal niches. By combining multiomic profiling, animal models, and organoid culture, new studies have not only demonstrated the roles of diverse mesenchymal cell populations but also defined the mechanisms underlying their regulation of niche signals. Focusing on several digestive organs, we describe how similar and diverse mesenchymal cell populations promote organ development and maintain proper stem cell activity, and how the heterogeneity of mesenchymal niches is altered in digestive diseases such as inflammation and cancer.
Keywords : single-cell analysis, digestive organ development, stem cell niche, inflammation, cancer
논문정보
- Review Paper
- 2020년 12월 (BRIC 등록일 2020-12-23)
- 국외 연구진
- 생명과학 > 분자생물학
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