조윤경 (IBS, UNIST)

한빛사논문

조회642

IBS, UNIST

CV File 373 kb

Nano Lett., Published online11 December 2020 | https://doi.org/10.1021/acs.nanolett.0c03639 Surface-Textured Mixed-Metal-Oxide Nanocrystals as Efficient Catalysts for ROS Production and Biofilm Eradication

Nitee Kumari,^1,4 Sumit Kumar,^2,4 Mamata Karmacharya,² Sateesh Dubbu,¹ Taewan Kwon,¹Varsha Singh,³ Keun Hwa Chae,³ Amit Kumar,^1* Yoon-Kyoung Cho,^2* In Su Lee^1*

¹Creative Research Initiative Center for Nanospace-confined Chemical Reactions (NCCR) and Department of Chemistry, Pohang University of Science and Technology (POSTECH),
Pohang 37673 (South Korea)
²Center for Soft and Living Matter, Institute for Basic Science (IBS) and Department of Biomedical Engineering, School of Life Sciences, Department of Chemical Engineering, School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919 (South Korea)
³Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, 02792, (South Korea)
⁴Equally contributing first authors.

^*Correspondence

Abstract

Next-generation catalysts are urgently needed to tackle the global challenge of antimicrobial resistance. Existing antimicrobials cannot function in the complex and stressful chemical conditions found in biofilms, and as a result, they are unable to infiltrate, diffuse into, and eradicate the biofilm and its associated matrix. Here, we introduce mixed-FeCo-oxide-based surface-textured nanostructures (MTex) as highly efficient magneto-catalytic platforms. These systems can produce defensive ROS over a broad pH range and can effectively diffuse into the biofilm and kill the embedded bacteria. Because the nanostructures are magnetic, biofilm debris can be scraped out of the microchannels. The key antifouling efficacy of MTex originates from the unique surface topography that resembles that of a ploughed field. These are captured as stable textured intermediates during the oxidative annealing and solid-state conversion of β-FeOOH nanocrystals. These nanoscale surfaces will advance progress toward developing a broad array of new enzyme-like properties at the nanobio interface.

논문정보

형식Research article
게재일2020년 12월 (BRIC 등록일 2020-12-21)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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