한빛사논문
Seung Won Lee1, Jee Myung Yang2, In Kyung Yoo3, Sung Yong Moon1, Eun Kyo Ha4, Abdullah Özgür Yeniova5, Joo Young Cho3, Min Seo Kim6, Jae Il Shin7, Dong Keon Yon8,9
1Department of Data Science, Sejong University, Seoul, Korea (the Republic of)
2Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
3Department of Gastroenterology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea (the Republic of)
4Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea (the Republic of)
5Division of Gastroenterology, Department of Internal Medicine, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey
6Genomics and Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Korea (the Republic of)
7Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
8Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea (the Republic of)
9Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
SWL, JMY and IKY are joint first authors.
Correspondence to Dr. Dong Keon Yon
Abstract
We appreciate the comment and discussion from Dr Roulet1 on our original article.2 The author criticised that (1) our study did not consider the dose-dependent exposure to proton pump inhibitors (PPIs); (2) our study did not investigate the relationship of PPI use in hospitalised patients with COVID-19 during treatment for COVID-19 and (3) although our study accounted for protopathic bias by excluding new non-steroidal anti-inflammatory drug users, protopathic bias occurred in patients who responded to the early digestive symptoms of COVID-19. We acknowledge that plausible academic concerns have been raised, which might improve the original discussion and extend the insight into the association between PPI usage and COVID-19.1 We have performed a post-hoc analysis from the Korean nationwide cohort, addressing these concern...
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