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한국체육대학교

Neurosci. Res., Volume 69, Issue 2, February 2011, Pages 161-173 | https://doi.org/10.1016/j.neures.2010.10.004 Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

Hyun-Sub Um^b, Eun-Bum Kang^a, Jung-Hoon Koo^a, Hyun-Tae Kim^a, Jin-Lee^c, Eung-Joon Kim^d, Chun-Ho Yang^e, Gil-Young An^a, In-Ho Cho^a, Joon-Yong Cho^a,*

^aExercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul 138-763, Republic of Korea
^bDepartment of Exercise Prescription, Kon-Yang University, 119 Daehangro, Nonsan city, Chungnam 320-711, Republic of Korea
^cDepartment of Anatomy and Cell Biology, College of Medicine, Han-Yang University, Seoul 133-791, Republic of Korea
^dDepartment of Physical Education, Kyonggi University, 94-6 Yiui-Dong Yeongtong-Gu, Suwon, Gyeonggi-Do 443-760, Republic of Korea
^eDepartment of Aviation and Marine Sports, University of Han-Seo, Seosansi 306-706, Republic of Korea

^*Corresponding author

Abstract

The present study was undertaken to further investigate the protective effect of treadmill exercise on the hippocampal proteins associated with neuronal cell death in an aged transgenic (Tg) mice with Alzheimer's disease (AD). To address this, Tg mouse model of AD, Tg-NSE/PS2m, which expresses human mutant PS2 in the brain, was chosen. Animals were subjected to treadmill exercise for 12 weeks from 24 months of age. The exercised mice were treadmill run at speed of 12 m/min, 60 min/day, 5 days/week on a 0% gradient for 3 months. Treadmill exercised mice improved cognitive function in water maze test. Treadmill exercised mice significantly reduced the expression of Aβ-42, Cox-2, and caspase-3 in the hippocampus. In parallel, treadmill exercised Tg mice decreased the phosphorylation levels of JNK, p38MAPK and tau (Ser404, Ser202, Thr231), and increased the phosphorylation levels of ERK, PI3K, Akt and GSK-3α/β. In addition, treadmill exercised Tg mice up-regulated the expressions of NGF, BDNF and phospho-CREB, and the expressions of SOD-1, SOD-2 and HSP-70. Treadmill exercised Tg mice up-regulated the expression of Bcl-2, and down-regulated the expressions of cytochrome c and Bax in the hippocampus. The number of TUNEL-positive cells in the hippocampus in mice was significantly decreased after treadmill exercise. Finally, serum TC, insulin, glucose, and corticosterone levels were significantly decreased in the Tg mice after treadmill exercise. As a consequence of such change, Aβ-dependent neuronal cell death in the hippocampus of Tg mice was markedly suppressed following treadmill exercise. These results strongly suggest that treadmill exercise provides a therapeutic potential to inhibit both Aβ-42 and neuronal death pathways. Therefore, treadmill exercise may be beneficial in prevention or treatment of AD.

논문정보

형식Research article
게재일2011년 02월 (BRIC 등록일 2021-02-10)
연구진국내 연구진
분야
피인용횟수120회 이상 인용된 논문

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