이규성 (성균관대학교 의과대학, 삼성서울병원) | 한빛사논문 > 한빛사

성균관대학교 의과대학, 삼성서울병원

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Sci. Adv., 11 Nov 2020: Vol. 6, no. 46, eabc9675 | DOI: 10.1126/sciadv.abc9675 Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder

Tae-Min Jang^1,*, Joong Hoon Lee^1,*, Honglei Zhou^2,3,*, Jaesun Joo⁴, Bong Hee Lim⁵, Huanyu Cheng², Soo Hyun Kim^1,6, Il-Suk Kang⁷, Kyu-Sung Lee^4,5,8,†, Eunkyoung Park^4,8,† and Suk-Won Hwang^1,†

¹KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
²Department of Engineering Science and Mechanics, Penn State University, University Park, PA, USA.
³Department of Engineering Mechanics, School of Mechanics, Civil Engineering and Architecture, Northwestern Polytechnical University, Xi’an, P.R. China.
⁴Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
⁵Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
⁶Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
⁷National NanoFab Center, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
⁸Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.

^†Corresponding author.
^*These authors contributed equally to this work.

Abstract

Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with substantial volume changes up to ~300%. The system configuration of the electronics validated by the theoretical model allows conformal, seamless integration onto the urinary bladder without a glue or suture, enabling precise monitoring with various electrical components for real-time status and efficient optogenetic manipulation for urination at the desired time. In vivo experiments using diabetic DUA models demonstrate the possibility for practical uses of high-fidelity electronics in clinical trials associated with the bladder and other elastic organs.

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TOP52020년 후보

형식Research article
게재일2020년 11월 (BRIC 등록일 2020-11-17)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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