구.농수식품
- 조회358
경북대학교 수의과대학
Abstract
Dong‑Ha Lee1, Biruk Tesfaye Birhanu1, Eon‑Bee Lee1, Seung‑Jin Lee2, Naila Boby1, Yong‑Soo Park3,*
and Seung‑Chun Park1,*
1Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Bukgu, Daegu 41566, Republic of Korea. 2Developmental and Reproductive Toxicology Research Group, Korean Institute of Toxicology, Daejeon 34114, Republic of Korea. 3Department of Equine Industry, Korea National College of Agriculture and Fisheries, Jeonju 54874, Republic of Korea.
*Correspondence
Cefquinome is administered in horses for the treatment of respiratory infection caused by Streptococcus equi subsp. zooepidemicus, and septicemia caused by Escherichia coli. However, there have been no attempts to use cefquinome against Streptococcus equi subsp. equi (S. equi), the causative agent of strangles. Hence the objective of this study was to calculate an optimal dosage of cefquinome against S. equi based on pharmacokinetics and pharmacodynamics integration. Cefquinome (1.0 mg/kg) was administered by intravenous and intramuscular routes to six healthy thoroughbred foals. Serum cefquinome concentrations were determined by high-performance liquid chromatography. The in vitro and ex vivo antibacterial activity were determined from minimum inhibitory concentrations (MIC) and bacterial killing curves. The optimal dosage was calculated from the integration of pharmacokinetic parameters and area under the curve (AUC24h/MIC) values. Total body clearance and volume of distribution of cefquinome after intravenous administration were 0.06 L/h/kg and 0.09 L/kg, respectively. Following intramuscular administration, a maximum concentration of 0.73 μg/mL at 1.52 h (Tmax) and a systemic bioavailability of 37.45% were observed. The MIC of cefquinome against S. equi was 0.016 μg/mL. The ex vivo AUC24h/MIC values representing bacteriostatic, and bactericidal activity were 113.11, and 143.14 h, respectively. Whereas the %T > MIC for bactericidal activity was 153.34%. In conclusion, based on AUC24h/MIC values and pharmacokinetic parameters, cefquinome when administered by intramuscularly at a dosage of 0.53 mg/kg every 24 h, would be effective against infection caused by S. equi in foals. Further studies may be necessary to confirm its therapeutic efficacy in a clinical environment.
Keywords : cefquinome, Streptococcus equi subsp. equi , antibacterial activity, PK/PD integration, optimal dosage
논문정보
- Research article
- 2020년 10월 (BRIC 등록일 2021-04-12)
- 국내 연구진
- 구・농수식품
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