구.농수식품
- 조회491
Abstract
Byeonghwi Lim1, Sangwook Kim1, Kyu‑Sang Lim2, Chang‑Gi Jeong3, Seung‑Chai Kim3, Sang‑Myeong Lee4, Choi‑Kyu Park5, Marinus F. W. te Pas6, Haesu Gho7, Tae‑Hun Kim7, Kyung‑Tai Lee7,*, Won‑Il Kim3,* and Jun‑Mo Kim1,*
1Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi‑do 17546, Republic of Korea. 2Department of Animal Science, Iowa State University, Ames, IA 50011, USA. 3College of Veterinary Medicine, Jeonbuk National University, Iksan, Jeollabuk‑do 54596, Republic of Korea. 4College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungcheongbuk‑do 28644, Republic of Korea. 5College of Veterinary Medicine & Animal Disease Intervention Center, Kyungpook National University, Daegu 41566, Republic of Korea. 6Wageningen UR Livestock Research, Wageningen, The Netherlands. 7Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA, Wanju 55365, Republic of Korea.
*Correspondence
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) infection is the most important viral disease causing severe economic losses in the swine industry. However, mechanisms underlying gene expression control in immunity-responsible tissues at different time points during PRRSV infection are poorly understood. We constructed an integrated gene co-expression network and identified tissue- and time-dependent biological mechanisms of PRRSV infection through bioinformatics analysis using three tissues (lungs, bronchial lymph nodes [BLNs], and tonsils) via RNA-Seq. Three groups with specific expression patterns (i.e., the 3-dpi, lung, and BLN groups) were discovered. The 3 dpi-specific group showed antiviral and innate-immune signalling similar to the case for influenza A infection. Moreover, we observed adaptive immune responses in the lung-specific group based on various cytokines, while the BLN-specific group showed down-regulated AMPK signalling related to viral replication. Our study may provide comprehensive insights into PRRSV infection, as well as useful information for vaccine development.
논문정보
- Research article
- 2020년 10월 (BRIC 등록일 2021-04-02)
- 국내(교신)+국외 연구진
- 생명과학 > 생물공학
- 구・농수식품
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