한빛사논문
- 조회756
Jung Hwan Shina,b, Min Songc, Se-Bum Paikc, and Min Whan Junga,b,d,1
aGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea; bCenter for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 34141, South Korea; cDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea; and dDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea
1To whom correspondence may be addressed.
Abstract
To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatal neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatal neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatal neuronal ensemble activity in the control of behavior.
striatum, calcium imaging, probabilistic classical conditioning, valuereward
논문정보
- Research article
- 2020년 10월 (BRIC 등록일 2020-10-19)
- 국내 연구진
- 생명과학 > 신경생물학
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