한빛사논문
- 조회1,127
Jaeeon Lee, Wengang Wang and Bernardo L. Sabatini*
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
*Corresponding author
Abstract
In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel. Although topographically arranged BG circuits have been described, the extent to which these relationships are maintained across the BG output nuclei and in downstream targets is unclear. Here, using focal trans-synaptic anterograde tracing, we show that the motor-action-related topographical organization of the striatum is preserved in all BG output nuclei. The topography is also maintained downstream of the BG and in multiple parallel closed loops that provide striatal input. Furthermore, focal activation of two distinct striatal regions induces either licking or turning, consistent with their respective anatomical targets of projection outside of the BG. Our results confirm the parallel model of BG function and suggest that the integration and competition of information relating to different behavior occur largely outside of the BG.
논문정보
- Research article
- 2020년 09월 (BRIC 등록일 2020-10-06)
- 국외 연구진
- 생명과학 > 생리학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
