한빛사논문
- 조회1,307
Eun Young Choi1,9, Hee Ho Park2,9, Hyelim Kim3,9, Hong Nam Kim4,5, Inyoung Kim6, Soyoung Jeon6, Wantae Kim6,*, Jong-Sup Bae7,* and Wonhwa Lee8,*
1Division of Pulmonary and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Respiratory Center, Yeungnam University Medical Center, Daegu, Republic of Korea
2Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea
3College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
4Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
5Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea
6Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Korea
7College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu, Republic of Korea
8Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
9These authors contributed equally to this work
*Corresponding authors
Abstract
The coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread globally, thereby resulting in declaration of pandemic emergency [1]. COVID-19 patients suffer from various infectious symptoms, including pneumonia, acute respiratory distress syndrome (ARDS) and sepsis. Some known-antiviral drugs, including remdesivir, have been proposed as effective agents for the treatment of SARS-CoV-2 infection [2, 3]. Along with the development of potential therapeutics, there is also urgency to mitigate the transmission and economic crisis of SARS-CoV-2 via identification of biomarkers that can rapidly indicate the severity of the disease in infected patients. Wnt ligands are secreted glycoproteins and their downstream signalling plays a pivotal role in embryonic development and tissue homeostasis. With remarkable progress in the immunology field, Wnt signalling has gained much attention as a critical regulator in various inflammatory diseases. A large body of evidence has suggested that Wnt ligands were secreted by immune cells, such as PBMCs, and non-immune cells, including stroma cell, to regulate inflammatory response and immune cell modulation [4–7]. In addition to their roles in inflammation, recent studies have reported that these Wnt ligands play key roles in tissue damage and repair [6]. Interestingly, previous studies have reported significant alterations in Wnt5a and Wnt11 expression compared to other Wnt ligands by analysing sera of patients with severe sepsis or sepsis mouse model [4, 8]. Wnt5a signalling has been known to activate in sepsis or ARDS and play a pivotal role in lung inflammation and fibrosis [5, 9], whereas Wnt11 protein has been reported to suppress induction of inflammatory cytokines by regulating NF-κB activity [10, 11]. Previous reports have demonstrated that Wnt5a and Wnt11 have opposite functions to one another in response to inflammation [12, 13]; hence it is thought that Wnt5a has pro-inflammatory effect and Wnt11 may be anti-inflammatory effect. Therefore, we focused on Wnt5a and Wnt11 to explore their potential relevance to COVID-19-related diseases. In this study, we report Wnt5a and Wnt11 as reliable biomarkers for monitoring of pathological progression in SARS-CoV-2 patients.
논문정보
TOP52020년 선정
- Research article
- 2020년 08월 (BRIC 등록일 2020-09-02)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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