한빛사논문, 상위피인용논문
- 조회1,570
Jee Myung Yang MD, PhD1,†, Hyun Yong Koh MD, PhD2,†, Sung Yong Moon BS3,†, In Kyung Yoo MD, PhD4, Eun Kyo Ha MD5, Seulgi You MD6, So Young Kim MD, PhD7, Dong Keon Yon MD8,9,∗, Seung Won Lee MD, PhD3,∗
1Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
2F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts
3Department of Data Science, Sejong University College of Software Convergence, Seoul, Republic of Korea
4Department of Gastroenterology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
5Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
6Department of Radiology, Ajou university hospital, Ajou University School of Medicine, Suwon, Republic of Korea
7Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
8Armed Force Medical Command, Republic of Korea Armed Forces, Seongnam, Republic of Korea
9Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
†Jee Myung Yang, Hyun Yong Koh, and Sung Yong Moon contributed equally to this work.
∗Dong Keon Yon and Seung Won Lee contributed equally as corresponding authors
Abstract
Background
There is inconclusive and controversial evidence of the association between allergic diseases and the risk of adverse clinical outcomes of the coronavirus disease (COVID-19).
Objective
To determine the association of allergic disorders with the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and with clinical outcomes of COVID-19 (admission to intensive care unit, administration of invasive ventilation, and death).
Methods
A propensity-score-matched nationwide cohort study was performed in South Korea. Data obtained from the Health Insurance Review & Assessment Service of Korea from all adult patients (age >20 years) who were tested for SARS-CoV-2 in South Korea between January 1, 2020 and May 15, 2020 were analyzed. The association of SARS-CoV-2 test positivity and allergic diseases in the entire cohort (n=219,959) and the difference of clinical outcomes of COVID-19 were evaluated in patients with allergic diseases and SARS-CoV-2 positivity (n=7340).
Results
In the entire cohort, patients who underwent SARS-CoV-2 testing were evaluated to ascertain whether asthma and allergic rhinitis were associated with an increased likelihood of SARS-CoV-2 test positivity. After propensity score matching, we found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 positivity. Patients with non-allergic asthma had a greater risk of SARS-CoV-2 test positivity and worse clinical outcomes of COVID-19 than patients with allergic asthma.
Conclusion
In a Korean nationwide cohort, allergic rhinitis and asthma, especially non-allergic asthma, confers a greater risk of susceptibility to SARS-CoV-2 infection and severe clinical outcomes of COVID-19.
논문정보
- Research article
- 2020년 08월 (BRIC 등록일 2020-08-20)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
- 60회 이상 인용된 논문 (상위피인용논문 등록일 2021-10-25)
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