한빛사논문
- 조회1,574
Xing Liu1,9, Ted Hong2,3,9, Sreeja Parameswaran2, Kevin Ernst2, Ivan Marazzi4,5, Matthew T. Weirauch2,6,7,10,*, Juan I. Fuxman Bass1,8,10,*
1Biology Department, Boston University, Boston, MA 02215, USA
2Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
3Department of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA
4Department of Microbiology, Mount Sinai Hospital Icahn School of Medicine, New York, NY 10029-5674, USA
5Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
7Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
8Bioinformatics Program, Boston University, Boston, MA 02215, USA
9These authors contributed equally
10Senior author
*Corresponding author
Abstract
Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
논문정보
- Review Paper
- 2020년 07월 (BRIC 등록일 2020-07-15)
- 국외 연구진
- 생명과학 > 유전자발현
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