한빛사논문, 상위피인용논문
- 조회2,511
Yasuo Oguri1,2,3,4,13, Kosaku Shinoda1,2,3,5,13, Hyeonwoo Kim6,13, Diana L. Alba1,7,14, W. Reid Bolus1,7,14, Qiang Wang1,2,3,4, Zachary Brown1,2,3, Rachana N. Pradhan1,2,3, Kazuki Tajima1,2,3, Takeshi Yoneshiro1,2,3, Kenji Ikeda1,2,3,8, Yong Chen1,2,3,9, Rachel T. Cheang1,7, Kazuyuki Tsujino10, Caroline R. Kim6, Vanille Juliette Greiner1,11, Ritwik Datta12, Christopher D. Yang12, Kamran Atabai12, Michael T. McManus1,11, Suneil K. Koliwad1,7,15, Bruce M. Spiegelman6,15, Shingo Kajimura1,2,3,4,16,*
1UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA
2Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA
3Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA
4Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes & Metabolism, Harvard Medical School, Boston, MA, USA
5Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA
6Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
7Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
8Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan
9Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
10Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Osaka, Japan
11Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA
12Department of Medicine, Lung Biology Center, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
13These authors contributed equally
14These authors contributed equally
15These authors contributed equally
16Lead Contact
*Corresponding author
Abstract
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with αV/β1 and αV/β5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis.
Keywords : brown fat; beige fat; adipocyte progenitors; adipogenesis; tissue remodeling; metabolism; metabolic disease; obesity; diabetes; metabolic adaptation
논문정보
- Research article
- 2020년 07월 (BRIC 등록일 2020-07-08)
- 국외 연구진
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2023-06-28)
댓글 작성 로그인
팝업 닫기관련 링크
