한빛사논문
Hyung-Seop Han, Indong Jun, Hyun-Kwang Seok, Kang-Sik Lee, Kyungwoo Lee, Frank Witte, Diego Mantovani, Yu-Chan Kim,* Sion Glyn-Jones,* and James R. Edwards*
Dr. H.-S. Han, Dr. H.-K. Seok, K. Lee, Dr. Y.-C. Kim
Center for Biomaterials, Biomedical Research Institute
Korea Institute of Science and Technology
Seoul 02792, Republic of Korea
Dr. H.-S. Han, Dr. I. Jun, Prof. S. Glyn-Jones, Prof. J. R. Edwards
Botnar Research Centre, Nuffeld Department of Orthopaedics,
Rheumatology and Musculoskeletal Sciences (NDORMS)
University of Oxford
Oxford OX3 7LD, UK
Dr. I. Jun
Environmental Safety Group
Korea Institute of Science & Technology Europe
Saarbrücken 66123, Germany
Dr. K.-S. Lee
Biomedical Engineering Research Center, Asan Institute for Life Sciences
Asan Medical Center, College of Medicine, University of Ulsan
Seoul 05505, Republic of Korea
Prof. F. Witte
Department of Prostodontics, Geriatric Dentistry and Craniomandibular Disorders
Charité-Universitätsmedizin Berlin
Berlin 14197, Germany
Prof. D. Mantovani
Laboratory for Biomaterials and Bioengineering, CRC-I, Dept.
Min-Met-Materials Engineering & CHU de Québec Research Center
Laval University
Quebec G1V 0A6, Canada
H.-S.H. and I.J. contributed equally to this work.
*Corresponding author
Abstract
Biodegradable metallic materials represent a potential step‐change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and fully biodegradable in vivo, removing the need for secondary surgery or long‐term complications. Here, it is shown how clinically approved Mg alloy promotes improved bone repair using an integrated state of the art fetal mouse metatarsal assay coupled with in vivo preclinical studies, second harmonic generation, secretome array analysis, perfusion bioreactor, and high‐resolution 3D confocal imaging of vasculature within skeletal tissue, to reveal a vascular‐mediated pro‐osteogenic mechanism controlling enhanced tissue regeneration. The optimized mechanical properties and corrosion rate of the Mg alloy lead to a controlled release of metallic Mg, Ca, and Zn ions at a rate that facilitates both angiogenesis and coupled osteogenesis for better bone healing, without causing adverse effects at the implantation site. The findings from this study support ongoing development and refinement of biodegradable metal systems to act as crucial portal technologies with significant potential to improve many clinical applications.
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