한빛사논문
- 조회1,463
Hyoung F. Kim1,3,*, Whitney S. Griggs2, Okihide Hikosaka2
1School of Biological Sciences, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea
2Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
3Lead Contact
*Corresponding author
Abstract
The thalamus is known to process information from various brain regions and relay it to other brain regions, serving an essential role in sensory perception and motor execution. The thalamus also receives inputs from basal ganglia nuclei (BG) involved in value-based decision making, suggesting a role in the value process. We found that neurons in a particular area of the rhesus macaque posterior thalamus encoded the historical value memory of visual objects. Many of these value-coding neurons were located in the suprageniculate nucleus (SGN). This thalamic area directly received anatomical input from the superior colliculus (SC), and the neurons showed visual responses with contralateral preferences. Notably, the value discrimination activity of these thalamic neurons increased during learning, with the learned values stably retained even more than 200 days after learning. Our data indicate that single neurons in the posterior thalamus not only processed simple visual information but also represented historical values. Furthermore, our data suggest an SC-posterior thalamus-BG-SC subcortical loop circuit that encodes the historical value, enabling a quick automatic gaze by bypassing the visual cortex.
Keywords : monkey; thalamus; long-term memory; visual object; object value; suprageniculate nucleus; superior colliculus; tail of the caudate nucleus; habit; subcortical visual pathway
논문정보
- Research article
- 2020년 06월 (BRIC 등록일 2020-06-23)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
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