한빛사논문
- 조회3,216
Key-Hwan Lima,*, Jae-Yeol Jooa, Kwang-Hyun Baekb
aNeurodegenerative Diseases Research Group, Korea Brain Research Institute, Choeomdan-Ro 61, Dong-Gu, Daegu 41068, Republic of Korea
bDepartment of Biomedical Science, CHA University, Gyeonggi-Do 13488, Republic of Korea
*Corresponding author
Abstract
Most proteins undergo posttranslational modification such as acetylation methylation, phosphorylation, biotinylation, and ubiquitination to regulate various cellular processes. Ubiquitin-targeted proteins from the ubiquitin-proteasome system (UPS) are degraded by 26S proteasome, along with this, deubiquitinating enzymes (DUBs) have specific activity against the UPS through detaching of ubiquitin on ubiquitin-targeted proteins. Balancing between protein expression and degradation through interplay between the UPS and DUBs is important to maintain cell homeostasis, and abnormal expression and elongation of proteins lead to diverse diseases such as cancer, diabetes, and auto-immune response. Therefore, development of DUB inhibitors as therapeutic targets has been challenging. In addition, understanding of the roles of DUBs in neurodegeneration, specifically brain diseases, has emerged gradually. This review highlights recent studies on the molecular mechanisms for DUBs, and discuss potential therapeutic targets for DUBs in cases of brain diseases.
Keywords : Neurodegenerative disease, Ubiquitin, Ubiquitination, Deubiquitinating enzyme
논문정보
- Review Paper
- 2020년 05월 (BRIC 등록일 2020-06-08)
- 국내 연구진
- 생명과학 > 신경생물학
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