한빛사논문
- 조회952
Hyungjun Kim†,‡,#, Heung Soo Lee§,#, Yale Jeon§, Woohyun Park¥, Yue Zhang∥, Bongjoong Kim¥, Hanmin Jang§, Baoxing Xu∥, Yoon Yeo‡,*, Dong Rip Kim§,*, Chi Hwan Lee†,¥,⊥,£,*
†Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
‡Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
§School of Mechanical Engineering, Hanyang University, Seoul, South Korea
¥School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
∥Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, United States
⊥School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, United States £Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana 47907, United States
Author Contributions
#H.K. and H.L. contributed equally to this work.
*Corresponding Authors
Abstract
Conventional melanoma therapies suffer from the toxicity and side effects of repeated treatments due to the aggressive and recurrent nature of melanoma cells. Less-invasive topical chemotherapies by utilizing polymeric microneedles have emerged as an alternative, but the sustained, long-lasting release of drug cargos remains challenging. In addition, the size of the microneedles is relatively bulky for the small, curvilinear, and exceptionally sensitive cornea for the treatment of ocular melanoma. Here, we report a design of bioresorbable, miniaturized porous-silicon (p-Si) needles with covalently linked drug cargos at doses comparable to those of conventional polymeric microneedles. The p-Si needles are built on a water-soluble film as a temporary flexible holder that can be intimately interfaced with the irregular surface of living tissues, followed by complete dissolution with saline solution within 1 min. Consequently, the p-Si needles remain embedded inside tissues and then undergo gradual degradation, allowing for sustained release of the drug cargos. Its utility in unobtrusive topical delivery of chemotherapy with minimal side effects is demonstrated in a murine melanoma model.
논문정보
- Research article
- 2020년 05월 (BRIC 등록일 2020-06-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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