정광훈 (기초과학연구원, 연세대학교, Massachusetts Institute of Technology, Broad Institute of Harvard University and MIT)

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기초과학연구원, 연세대학교, Massachusetts Institute of Technology, Broad Institute of Harvard University and MIT

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Nat. Methods, Published: 18 May 2020 | https://doi.org/10.1038/s41592-020-0823-y Elasticizing tissues for reversible shape transformation and accelerated molecular labeling

Taeyun Ku^1,2,10, Webster Guan³, Nicholas B. Evans^1,2, Chang Ho Sohn^1,2,11,12, Alexandre Albanese¹, Joon-Goon Kim⁴, Matthew P. Frosch⁵ and Kwanghun Chung^{1,2,3,6,7,8,9,*}

¹Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. ²Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA. ³Department of Chemical Engineering, MIT, Cambridge, MA, USA. ⁴Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ⁵C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. ⁶Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA. ⁷Broad Institute of Harvard University and MIT, Cambridge, MA, USA. ⁸Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea. ⁹Nano Biomedical Engineering (Nano BME) Graduate Program, Yonsei-IBS Institute, Yonsei University, Seoul, Republic of Korea. ¹⁰Present address: Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea. ¹¹Present address: Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea. ¹²Present address: Nano Biomedical Engineering (Nano BME) Graduate Program, Yonsei-IBS Institute, Yonsei University, Seoul, Republic of Korea.

^*Corresponding author

Abstract

We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

논문정보

형식Research article
게재일2020년 05월 (BRIC 등록일 2020-06-09)
연구진국내(교신)+국외 연구진
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