한빛사논문
- 조회2,719
Hae-Ock Lee1,2,25, Yourae Hong1,3,25, Hakki Emre Etlioglu4,25, Yong Beom Cho3,5,25, Valentina Pomella4, Ben Van den Bosch4, Jasper Vanhecke4, Sara Verbandt4, Hyekyung Hong5, Jae-Woong Min1, Nayoung Kim1,2, Hye Hyeon Eum1,2, Junbin Qian6,7, Bram Boeckx6,7, Diether Lambrechts6,7, Petros Tsantoulis8,9,10, Gert De Hertogh11,12, Woosung Chung1, Taeseob Lee1,13, Minae An1,3, Hyun-Tae Shin1, Je-Gun Joung1, Min-Hyeok Jung14, Gunhwan Ko15, Pratyaksha Wirapati16, Seok Hyung Kim17, Hee Cheol Kim5, Seong Hyeon Yun5, Iain Bee Huat Tan18,19,20, Bobby Ranjan21, Woo Yong Lee5, Tae-You Kim22, Jung Kyoon Choi23, Young-Joon Kim14,24, Shyam Prabhakar21, Sabine Tejpar 4,26,* and Woong-Yang Park1,2,3,26,*
1Samsung Genome Institute, Samsung Medical Center, Seoul, Korea. 2Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea. 3Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea. 4Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium. 5Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 6Center for Cancer Biology, VIB, Leuven, Belgium. 7Laboratory for Translational Genetics, Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium. 8Centre d’Oncologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland. 9Service d’Oncologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland. 10Université de Genève, Geneva, Switzerland. 11Department of Pathology, University Hospitals Leuven, Leuven, Belgium. 12Department of Imaging and Pathology, Leuven, Belgium. 13Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea. 14Department of Biochemistry, College of Life Science and Technology, Yonsei University, Seoul, Korea. 15Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. 16Swiss Institute of Bioinformatics, Lausanne, Switzerland. 17Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 18Division of Medical Oncology, National Cancer Center, Singapore, Singapore. 19Agency for Science, Technology and Research (A*STAR), Genome Institute of Singapore, Singapore, Singapore. 20Duke-National University of Singapore Medical School, Singapore, Singapore. 21Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. 22Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 23Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea. 24Department of Integrated OMICS for Biomedical Science, Yonsei University Graduate School, Seoul, Korea. 25These authors contributed equally: Hae-Ock Lee, Yourae Hong, Hakki Emre Etlioglu, Yong Beom Cho. 26These authors jointly supervised this work: Sabine Tejpar, Woong-Yang Park.
*Corresponding authors
Abstract
Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.
논문정보
- Research article
- 2020년 05월 (BRIC 등록일 2020-05-29)
- 국내(교신)+국외 연구진
- 의약학 > 유전 및 유전체의학
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