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Nanomedicine, Volume 9, Issue 13, 1 September 2014, Pages 2003-2022 | https://doi.org/10.2217/nnm.14.147 Gold nanoparticle-mediated photothermal therapy: current status and future perspective

Hwang, S.^a, Nam, J.^a, Jung, S.^b, Song, J.^b, Doh, H.^a, Kim, S.^a,b,*

^aDepartment of Chemistry, Pohang University of Science and Technology (POSTECH), San 31, Hyojadong, Namgu, Pohang, 790-784, South Korea
^bSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea

^*Corresponding author

Abstract

Gold nanoparticles (AuNPs) are attractive photothermal agents for cancer therapy because they show efficient local heating upon excitation of surface plasmon oscillations. The strong absorption, efficient heat conversion, high photostability, inherent low toxicity and well-defined surface chemistry of AuNPs contribute to the growing interest in their photothermal therapy (PTT) applications. The facile tunability of gold nanostructures enables engineering of AuNPs for superior near-infrared photothermal efficacy and target selectivity, which guarantee efficient and deep tissue-penetrating PTT with mitigated concerns regarding side effects by nonspecific distributions. This article discusses the current research findings with representative near-infrared-active AuNPs, which include nanoshell, nanorod, nanocage, nanostar, nanopopcorn and nanoparticle assembly systems. AuNPs successfully demonstrate potential for use in PTT, but several hurdles to clinical applications remain, including long-term toxicity and a need for sophisticated control over biodistribution and clearance. Future research directions are discussed, especially regarding the clinical translation of AuNP photosensitizers.

논문정보

형식Review Paper
게재일2014년 09월 (BRIC 등록일 2020-06-18)
연구진국내 연구진
분야
피인용횟수120회 이상 인용된 논문

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