한빛사논문
- 조회4,235
Jia Liu1,*, Yoon Seok Kim2,*, Claire E. Richardson3,*, Ariane Tom2,*, Charu Ramakrishnan2, Fikri Birey4, Toru Katsumata1, Shucheng Chen1, Cheng Wang5, Xiao Wang2, Lydia-Marie Joubert6, Yuanwen Jiang1, Huiliang Wang2, Lief E. Fenno2,4, Jeffrey B.-H. Tok1, Sergiu P. Pașca4, Kang Shen3,7, Zhenan Bao1,†, Karl Deisseroth2,4,7,†
1Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
2Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
3Department of Biology, Stanford University, Stanford, CA 94305, USA.
4Department of Psychiatry, Stanford University, Stanford, CA 94305, USA.
5Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley CA 94720, USA.
6Cell Sciences Imaging Facility, Stanford University, Stanford, CA 94305, USA.
7Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
†Corresponding author.
*These authors contributed equally to this work.
Abstract
The structural and functional complexity of multicellular biological systems, such as the brain, are beyond the reach of human design or assembly capabilities. Cells in living organisms may be recruited to construct synthetic materials or structures if treated as anatomically defined compartments for specific chemistry, harnessing biology for the assembly of complex functional structures. By integrating engineered-enzyme targeting and polymer chemistry, we genetically instructed specific living neurons to guide chemical synthesis of electrically functional (conductive or insulating) polymers at the plasma membrane. Electrophysiological and behavioral analyses confirmed that rationally designed, genetically targeted assembly of functional polymers not only preserved neuronal viability but also achieved remodeling of membrane properties and modulated cell type–specific behaviors in freely moving animals. This approach may enable the creation of diverse, complex, and functional structures and materials within living systems.
논문정보
- Research article
- 2020년 03월 (BRIC 등록일 2020-04-22)
- 국외 연구진
- 생명과학 > 생화학
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