한빛사논문, 상위피인용논문
- 조회2,699
Young-Il Kim1,2, Seong-Gyu Kim1, Se-Mi Kim1, Eun-Ha Kim1,2, Su-Jin Park1,2, Kwang-Min Yu1,2, Jae-Hyung Chang1, Eun Ji Kim1, Seunghun Lee1, Mark Anthony B. Casel1,2, Jihye Um4, Min-Suk Song1,2, Hye Won Jeong1, Van Dam Lai3, Yeonjae Kim4, Bum Sik Chin4, Jun-Sun Park4, Ki-Hyun Chung4, Suan-Sin Foo5, Haryoung Poo6, In-Pil Mo3, Ok-Jun Lee1, Richard J. Webby7, Jae U. Jung5,*, Young Ki Choi1,2,8,*
1College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea
2Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea
3College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea
4Research institute of Public Health, National Medical Center, Seoul, Republic of Korea
5Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
6Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon, Republic of Korea
7Division of Virology, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
8Lead Contact
*Corresponding author
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.
Keywords
2019-novel coronavirus; 2019-nCoV; severe acute respiratory syndrome coronavirus 2; SARS-CoV-2; novel coronavirus disease; COVID-19; virus shedding; transmission; ferrets
논문정보
- Research article
- 2020년 04월 (BRIC 등록일 2020-04-13)
- 국내(교신)+국외 연구진
- 의약학 > 감염의학
- 60회 이상 인용된 논문 (상위피인용논문 등록일 2020-10-23)
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