이용호 (연세대학교 의과대학)

한빛사 논문

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연세대학교 의과대학

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Am. J. Gastroenterol., March 03, 2020, Volume 115 - Issue 4 - p 584-595 | doi: 10.14309/ajg.0000000000000572 Nonalcoholic Fatty Liver Disease and Sarcopenia Are Independently Associated With Cardiovascular Risk

Han, Eugene MD, PhD¹; Lee, Yong-ho MD, PhD^2,3,*; Kim, Young Dae MD, PhD^4,*; Kim, Beom Kyung MD, PhD^2,5,6; Park, Jun Yong MD, PhD^2,5,6; Kim, Do Young MD, PhD^2,5,6; Ahn, Sang Hoon MD, PhD^2,5,6; Lee, Byung-Wan MD, PhD^2,3; Kang, Eun Seok MD, PhD^2,3; Cha, Bong-Soo MD, PhD^2,3; Han, Kwang-Hyub MD^2,5,6; Nam, Hyo Suk MD, PhD⁴; Heo, Ji Hoe MD, PhD⁴; Kim, Seung Up MD, PhD^2,5,6,*

¹Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea;
²Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
³Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea;
⁴Department of Neurology, Yonsei University College of Medicine, Seoul, Korea;
⁵Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea;
⁶Yonsei Liver Center, Severance Hospital, Seoul, Korea.

^*Corresponding author

Abstract

OBJECTIVES:
Nonalcoholic fatty liver disease (NAFLD) and sarcopenia have a close association with an increased risk of atherosclerotic cardiovascular disease (ASCVD). This study investigated the influence of NAFLD and sarcopenia on ASCVD risk.

METHODS:
Data from the 2008–2011 Korean National Health and Nutrition Examination Surveys database were analyzed (n = 7,191). The sarcopenia index was calculated using dual-energy x-ray absorptiometry. Sarcopenia was defined as the lowest quintile sarcopenia index value (cutoffs = 0.882 for men and 0.582 for women). NAFLD was defined as a comprehensive NAFLD score ≥40. Liver fibrosis was assessed using the fibrosis-4 (FIB-4) index. ASCVD risk was evaluated using American College of Cardiology/American Heart Association guidelines. High probability of ASCVD was defined as ASCVD risk >10%.

RESULTS:
The prevalence rates of NAFLD and sarcopenia were 31.2% (n = 2,241) and 19.5% (n = 1,400), respectively. The quartile-stratified ASCVD risk scores were positively associated with NAFLD and sarcopenia (all P for trend < 0.001). Subjects with both NAFLD and sarcopenia had a higher risk for high probability of ASCVD (odds ratio = 1.83, P = 0.014) compared with controls without NAFLD and sarcopenia. Among subjects with NAFLD, FIB-4–defined significant liver fibrosis and sarcopenia additively raised the risk for high probability of ASCVD (odds ratio = 3.56, P < 0.001) compared with controls without FIB-4–defined significant liver fibrosis or sarcopenia.

DISCUSSION:
NAFLD and sarcopenia were significantly associated with an increased risk of ASCVD in the general population. In addition, NAFLD with significant liver fibrosis and sarcopenia were significantly associated with an increased risk of ASCVD in subjects with NAFLD.

논문정보

형식Research article
게재일2020년 03월 (BRIC 등록일 2020-03-24)
연구진국내 연구진
분야 의약학 > 응용의학

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