한빛사논문
Jung Woo Leem1, Min Seok Kim2, Seung Ho Choi3, Seong-Ryul Kim4, Seong-Wan Kim4, Young Min Song2, Robert J. Young5 & Young L. Kim1,6,7,8,*
1 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
2 School of Electrical Engineering and Computer Science, Gwangju Institute of Science Technology, Gwangju 61005, Republic of Korea.
3 Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea.
4 Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea.
5 Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.
6 Purdue University Center for Cancer Research, West Lafayette, Indiana 47907, USA.
7 Regenstrief Center for Healthcare Engineering, West Lafayette, Indiana 47907, USA.
8 Purdue Quantum Science and Engineering Institute, West Lafayette, Indiana 47907, USA.
*Correspondence to Young L. Kim.
Abstract
Counterfeit medicines are a fundamental security problem. Counterfeiting medication poses a tremendous threat to patient safety, public health, and the economy in developed and less developed countries. Current solutions are often vulnerable due to the limited security levels. We propose that the highest protection against counterfeit medicines would be a combination of a physically unclonable function (PUF) with on-dose authentication. A PUF can provide a digital fingerprint with multiple pairs of input challenges and output responses. On-dose authentication can verify every individual pill without removing the identification tag. Here, we report on-dose PUFs that can be directly attached onto the surface of medicines, be swallowed, and digested. Fluorescent proteins and silk proteins serve as edible photonic biomaterials and the photoluminescent properties provide parametric support of challenge-response pairs. Such edible cryptographic primitives can play an important role in pharmaceutical anti-counterfeiting and other security applications requiring immediate destruction or vanishing features.
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