한빛사논문
- 조회1,117
성균관대학교, 기초과학연구원
Jiyoung Nama,b, Hyun-Kyoung Lima,b, Nam Hyeong Kimb, Jong Kwan Parkb, Eun Sung Kangb, Yong-Tae Kimb, Chaejeong Heoa, One-Sun Leec, Seong-Gi Kima,b, Wan Soo Yunb,*, Minah Suha,b,*, and Yong Ho Kima,b,*
aInstitute for Basic Science (IBS), Suwon, Korea
bSungkyunkwan University, Suwon, Korea
cHamad Bin Khalifa University, Doha, Qatar
*Corresponding Authors
J.N. and H.-K.L. contributed equally to this work.
Abstract
Recording neural activity from the living brain is of great interest in neuroscience for interpreting cognitive processing or neurological disorders. Despite recent advances in neural technologies, development of a soft neural interface that integrates with neural tissues, increases recording sensitivity, and prevents signal dissipation still remains a major challenge. Here, we introduce a biocompatible, conductive, and biostable neural interface, a supramolecular β-peptide-based hydrogel that allows signal amplification via tight neural/hydrogel contact without neuroinflammation. The non-biodegradable β-peptide forms a multihierarchical structure with conductive nanomaterial, creating a three-dimensional electrical network, which can augment brain signal efficiently. By achieving seamless integration in brain tissue with increased contact area and tight neural tissue coupling, the epidural and intracortical neural signals recorded with the hydrogel were augmented, especially in the high frequency range. Overall, our tissuelike chronic neural interface will facilitate a deeper understanding of brain oscillation in broad brain states and further lead to more efficient brain–computer interfaces.
KEYWORDS : hydrogel-based neural interface, supramolecular peptide, carbon nanotube, brain signals, three-dimensional electrical network
논문정보
- Research article
- 2020년 01월 (BRIC 등록일 2020-01-16)
- 국내(교신)+국외 연구진
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