한빛사논문
- 조회741
Suyeong Seo1,2, Hwieun Kim1,3, Jong Hwan Sung3, Nakwon Choi1,4, Kangwon Lee2,*, Hong Nam Kim1,4,*
1 Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
2 Program in Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea
3 Department of Chemical Engineering, Hongik University, Seoul 04066, Republic of Korea
4 Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea
*Correspondence : Kangwon Lee, Hong Nam Kim
Abstract
Central nervous system (CNS) diseases are emerging as a major issue in an aging society. Although extensive research has focused on the development of CNS drugs, the limited transport of therapeutic agents across the blood–brain barrier (BBB) remains a major challenge. Conventional two-dimensional culture dishes do not recapitulate in vivo physiology and real-time observations of molecular transport are not possible in animal models. Recent advances in engineering techniques have enabled the generation of more physiologically relevant in vitro BBB models, and their applications have expanded from fundamental biological research to practical applications in the pharmaceutical industry. In this article, we provide an overview of recent advances in the development of in vitro BBB models, with a particular focus on the recapitulation of BBB function. The development of biomimetic BBB models is postulated to revolutionize not only fundamental biological studies but also drug screening.
Keywords : Blood–brain barrier; neurovascular unit; in vitro models; physiological relevance; vascular permeability; drug screening
논문정보
- Review Paper
- 2019년 12월 (BRIC 등록일 2020-01-14)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
