정상윤 (University of Wisconsin)

한빛사논문

조회3,452

University of Wisconsin

CV File 89 kb

Cell, Vol 132, 783-793, 07 March 2008 The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species

Abstract

Sangyun Jeong,¹ Mark Rebeiz,¹ Peter Andolfatto,² Thomas Werner,¹ John True,³ and Sean B. Carroll^{1,
*}

¹ Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
² Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
³ Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794, USA

^*Corresponding author
Sean B. Carroll

Summary

Understanding the mechanisms underlying the morphological divergence of species is one of the central goals of evolutionary biology. Here, we analyze the genetic and molecular bases of the divergence of body pigmentation patterns between Drosophila yakuba and its sister species Drosophila santomea. We found that loss of pigmentation in D. santomea involved the selective loss of expression of the tan and yellow pigmentation genes. We demonstrate that tan gene expression was eliminated through the mutational inactivation of one specific tan cis-regulatory element (CRE) whereas the Tan protein sequence remained unchanged. Surprisingly, we identify three independent loss-of-function alleles of the tan CRE in the young D. santomea lineage. We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements.

논문정보

형식Research article
게재일2008년 03월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 신경생물학

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