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Adv. Drug Deliv. Rev., Available online 16 December 2019 | https://doi.org/10.1016/j.addr.2019.11.010 Non-transdermal microneedles for advanced drug delivery

KangJu Lee^a,b, Marcus J. Goudie^a,b, Peyton Tebon^a,b, Wujin Sun^a,b, Zhimin Luo^a,b, Junmin Lee^a,b, Shiming Zhang^a,b, Kirsten Fetah^a,b, Han-Jun Kim^a,b, Yumeng Xue^a,b, Mohammad Ali Darabi^a,b, Samad Ahadian^a,b, Einollah Sarikhani^a,b, WonHyoung Ryu^c, Zhen Gu^a,b,d,e, Paul S. Weiss^a,b,f, Mehmet R. Dokmeci^b,g, Nureddin Ashammakhi^b,g,*, Ali Khademhosseini^a,b,d,g,h,*

^aDepartment of Bioengineering and Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA
^bCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
^cDepartment of Mechanical Engineering, Yonsei University, Seoul 03722, South Korea
^dJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90024, USA
^eJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
^fDepartment of Chemistry and Biochemistry, Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
^gDepartment of Radiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
^hDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA

^*Corresponding authors

Abstract

Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically by penetrating restrictive tissue barriers in a minimally invasive manner. While much of the early development of MNs focused on transdermal drug delivery, this technology can be applied to a variety of other non-transdermal biomedical applications. Several variations, such as multi-layer or hollow MNs, have been developed to cater to the needs of specific applications. The heterogeneity in the design of MNs has demanded similar variety in their fabrication methods; the most common methods include micromolding and drawing lithography. Numerous materials have been explored for MN fabrication which range from biocompatible ceramics and metals to natural and synthetic biodegradable polymers. Recent advances in MN engineering have diversified MNs to include unique shapes, materials, and mechanical properties that can be tailored for organ-specific applications. In this review, we discuss the design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue.

Keywords : Microneedle; Implant; Drug delivery; Non-transdermal; Biocompatibility; Biodegradability

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형식Review Paper
게재일2019년 12월 (BRIC 등록일 2020-08-11)
연구진국내+국외 연구진
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