한빛사논문
- 조회2,212
Jaehoon Seola,b,1, Yuya Fujiib,1, Insung Parka, Yoko Suzukia, Fusae Kawanaa, Katsuhiko Yajimac, Shoji Fukusumia, Tomohiro Okurad, Makoto Satoha, Kumpei Tokuyamaa, Toshio Kokuboa, and Masashi Yanagisawaa,e,f,g,2
a International Institute for Integrative Sleep Medicine, University of Tsukuba, 305-8575 Tsukuba, Ibaraki, Japan; b Physical Education, Health, and Sport Sciences, University of Tsukuba, 305-8574 Tsukuba, Ibaraki, Japan; c Faculty of Health and Nutrition, Tokyo Seiei College, 124-8530 Tokyo, Japan; d Faculty of Health and Sport Sciences, University of Tsukuba, 305-8574 Tsukuba, Ibaraki, Japan; e Life Science Center for Survival Dynamics (TARA), University of Tsukuba, Ibaraki, 305-8577, Japan; f R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, Ibaraki, 305-8575, Japan; and g Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 J.S. and Y.F. contributed equally to this work.
2 To whom correspondence may be addressed
Abstract
The majority of patients with insomnia are treated with hypnotic agents. In the present study, we evaluated the side-effect profile of an orexin receptor antagonist and γ-aminobutyric acid A (GABAA) receptor agonist on physical/cognitive functions upon forced awakening. This double-blind, randomized, placebo-controlled, cross-over study was conducted on 30 healthy male subjects. Fifteen minutes before bedtime, the subjects took a pill of suvorexant (20 mg), brotizolam (0.25 mg), or placebo and were forced awake 90 min thereafter. Physical- and cognitive-function tests were performed before taking the pill, after forced awakening, and the next morning. Polysomnographic recordings revealed that the efficacies of the hypnotic agents in prolonging total sleep time (∼30 min) and increasing sleep efficiency (∼6%) were comparable. When the subjects were allowed to go back to sleep after the forced awakening, the sleep latency was shorter under the influence of hypnotic agents (∼2 min) compared to the placebo trial (24 min), and the rapid eye movement latency was significantly shorter under suvorexant (98.8, 81.7, and 48.8 min for placebo, brotizolam, and suvorexant, respectively). Although brotizolam significantly impaired the overall physical/cognitive performance (sum of z score) compared with placebo upon forced awakening, there was no significant difference in the total z score of performance between suvorexant and placebo. Notably, the score for static balance with the eyes open was higher under suvorexant compared to brotizolam administration. The energy expenditure was lower under suvorexant and brotizolam compared with the placebo. The effect size of brotizolam (d = 0.24) to reduce the energy expenditure was larger than that of suvorexant (d < 0.01).
hypnotics, benzodiazepines, Stroop color-word test, Purdue pegboard test, body sway
논문정보
- Research article
- 2019년 11월 (BRIC 등록일 2019-11-15)
- 국외 연구진
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