한빛사논문
- 조회1,883
Soyeon V. Parka,1, Jae-Seong Yangb,1, Hyesung Joa, Byunghwa Kanga, Seung Soo Oha,c,*, Gyoo Yeol Jungb,c,*
a Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, South Korea
b Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, South Korea
c School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, South Korea
1These authors contributed equally to this work.
*Correspondence to : , Gyoo Yeol Jung, Seung Soo Oh
Abstract
Ribozymes are functional RNA molecules that can catalyze biochemical reactions. Since the discovery of the first catalytic RNA, various functional ribozymes (e.g., self-cleaving ribozymes, splicing ribozymes, RNase P, etc.) have been uncovered, and their structures and mechanisms have been identified. Ribozymes have the advantage of possessing features of “RNA” molecules; hence, they are highly applicable for manipulating various biological systems. To fully employ ribozymes in a broad range of biological applications in synthetic biology, a variety of ribozymes have been developed and engineered. Here, we summarize the main features of ribozymes and the methods used for engineering their functions. We also describe the past and recent efforts towards exploiting ribozymes for effective and novel applications in synthetic biology. Based on studies on their significance in biological applications till date, ribozymes are expected to advance technologies in artificial biological systems.
Keywords : Ribozyme; Catalytic RNA; Self-cleavage; Splicing; Synthetic biology; Expression control; Detecting system; Logic circuit; Activity regulation; Gene editing
논문정보
- Review Paper
- 2019년 10월 (BRIC 등록일 2019-11-04)
- 국내 연구진
- 생명과학 > 생물공학
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