한빛사논문
- 조회2,020
Heejin Yoo1,3,7, George H. Greene1,7, Meng Yuan2,7, Guoyong Xu1,4, Derek Burton1, Lijing Liu1,5, Jorge Marqués1,6, Xinnian Dong1,*
1 Howard Hughes Medical Institute, Department of Biology, Duke University, Durham, North Carolina 27708, USA
2 National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research (Wuhan), Huazhong Agricultural University, 430070 Wuhan, China
3 Present address: Department of Plant Biology, Ecology, and Evolution, Oklahoma State University, Stillwater, Oklahoma 74078, USA
4 Present address: National Key Laboratory of Hybrid Rice, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, China
5 Present address: Key Laboratory of Plant Development and Environment Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, China
6 Present address: David H. Murdock Research Institute, Kannapolis, North Carolina 28081, USA.
7 These authors contributed equally to this work.
*Correspondence: Xinnian Dong
Abstract
Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity, when plants recognize microbe-associated molecular patterns. However, it is not fully known whether translational regulation also occurs in subsequent immune responses, such as effector-triggered immunity (ETI). In this study, we performed genome-wide ribosome profiling in Arabidopsis upon RPS2-mediated ETI activation and discovered that specific groups of genes were translationally regulated, mostly in coordination with transcription. These genes encode enzymes involved in aromatic amino acid, phenylpropanoid, camalexin, and sphingolipid metabolism. The functional significance of these components in ETI was confirmed by genetic and biochemical analyses. Our findings provide new insights into the diverse translational regulation in the plant immune responses and demonstrate that translational coordination of metabolic gene expression is an important strategy for ETI.
KEYWORDS : Translational regulation; Ribosome profiling; Effector-triggered immunity; ETI; phenylalanine; phenylpropanoids; helper receptors
논문정보
- Research article
- 2019년 09월 (BRIC 등록일 2019-10-07)
- 국외 연구진
- 생명과학 > 유전자발현
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