한빛사논문
- 조회1,060
Suchan Chang1, Dan Hyo Kim1, Eun Young Jang1, Seong Shoon Yoon1, Young Seob Gwak2, Yoo Jung Yi1, Jun Yeon Lee1, Song Hee Ahn1, Jin Mook Kim1, Yeon-Hee Ryu3, Seung-Nam Kim4, Hyo Sun Roh4, Mi-Young Lee5, Sang Chan Kim1, Bong Hyo Lee1, Hee Young Kim1,* and Chae Ha Yang1,*
1 College of Korean Medicine, Daegu Haany University, Daegu 42158, Republic of Korea.
2 Department of Anesthesiology, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA.
3 Acupuncture, Moxibustion & Meridian Research Center, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
4 College of Korean Medicine, Dongguk University, Goyang 10326, Republic of Korea.
5 College of Biomedical Science, Daegu Haany University, Gyeongbuk 38610, Republic of Korea.
*Corresponding author.
Abstract
A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for ARC β-endorphin neurons in alcohol dependence and acupuncture effects has not been examined. Here, we show that acupuncture at Shenmen (HT7) points attenuates behavioral manifestation of alcohol dependence by activating endorphinergic input to the NAc from the ARC. Acupuncture attenuated ethanol withdrawal tremor, anxiety-like behaviors, and ethanol self-administration in ethanol-dependent rats, which are mimicked by local injection of β-endorphin into the NAc. Acupuncture also reversed the decreased β-endorphin levels in the NAc and a reduction of neuronal activity in the ARC during ethanol withdrawal. These results suggest that acupuncture may provide a novel, potential treatment strategy for alcohol use disorder by direct activation of the brain pathway.
논문정보
- Research article
- 2019년 09월 (BRIC 등록일 2019-09-18)
- 국내(교신)+국외 연구진
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