한빛사논문
- 조회1,685
Hyogeun Shin1,2, Yoojin Son1, Uikyu Chae1,3, Jeongyeon Kim4, Nakwon Choi1,2, Hyunjoo J. Lee5, Jiwan Woo6, Yakdol Cho6, Soo Hyun Yang7, C. Justin Lee6 & Il-Joo Cho1,2,*
1 Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea. 2 Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Daejeon, Korea. 3 School of Electrical Engineering, Korea University, Seoul, Korea. 4 Korea Brain Research Institute, Daegu, Korea. 5 School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. 6 Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea. 7 Department of Anatomy, College of Medicine, Korea University, Seoul, Korea.
*Correspondence and requests for materials should be addressed to I.-J.C.
Abstract
Investigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for recording neural signals from different regions at the cellular level. In this work, we successfully demonstrated the functionality of our probe by confirming and modulating the functional connectivity between the hippocampal CA3 and CA1 regions in vivo.
논문정보
- Research article
- 2019년 08월 (BRIC 등록일 2019-09-02)
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