여운홍 (Georgia Institute of Technology) | 한빛사논문 > 한빛사

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Georgia Institute of Technology

Adv. Sci., First published: 07 August 2019 | https://doi.org/10.1002/advs.201901034 Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real‐Time Monitoring of Cerebral Aneurysm Hemodynamics

Robert Herbert^a, Saswat Mishra^a, Hyo-Ryoung Lim^a, Hyoungsuk Yoo^b, and Woon-Hong Yeo^a,c,*

^aGeorge W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA
^bDepartment of Biomedical Engineering, Hanyang University, Seoul 04763, South Korea
^cWallace H. Coulter Department of Biomedical Engineering, Parker H. Petit Institute for Bioengineering and Biosciences, Neural Engineering Center, Center for Flexible and Wearable Electronics Advanced Research Institute for Materials, Georgia Institute of Technology, Atlanta, GA 30332, USA

^*To whom correspondence should be addressed.

Abstract

This study introduces a high‐throughput, large‐scale manufacturing method that uses aerosol jet 3D printing for a fully printed stretchable, wireless electronics. A comprehensive study of nanoink preparation and parameter optimization enables a low‐profile, multilayer printing of a high‐performance, capacitance flow sensor. The core printing process involves direct, microstructured patterning of biocompatible silver nanoparticles and polyimide. The optimized fabrication approach allows for transfer of highly conductive, patterned silver nanoparticle films to a soft elastomeric substrate. Stretchable mechanics modeling and seamless integration with an implantable stent display a highly stretchable and flexible sensor, deployable by a catheter for extremely low‐profile, conformal insertion in a blood vessel. Optimization of a transient, wireless inductive coupling method allows for wireless detection of biomimetic cerebral aneurysm hemodynamics with the maximum readout distance of 6 cm through meat. In vitro demonstrations include wireless monitoring of flow rates (0.05–1 m s⁻¹) in highly contoured and narrow human neurovascular models. Collectively, this work shows the potential of the printed biosystem to offer a high throughput, additive manufacturing of stretchable electronics with advances toward batteryless, real‐time wireless monitoring of cerebral aneurysm hemodynamics.

Keywords : aerosol jet 3D printing, aerosol nanoparticles, batteryless wireless monitoring, hemodynamics, stretchable hybrid electronics

논문정보

형식Research article
게재일2019년 08월 (BRIC 등록일 2019-08-21)
연구진국내+국외 연구진
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