한빛사논문
- 조회1,652
Jeongyun Seo1, Woo Y. Byun 1, Farid Alisafaei2, Andrei Georgescu 1, Yoon-Suk Yi1, Mina Massaro-Giordano3,4, Vivek B. Shenoy2,5, Vivian Lee3, Vatinee Y. Bunya3,4 and Dongeun Huh1,5,6*
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. 2Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA. 3Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4Penn Dry Eye and Ocular Surface Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 5NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA. 6Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
*Correspondence to Dongeun Huh.
Abstract
Here we present a miniaturized analog of a blinking human eye to reverse engineer the complexity of the interface between the ocular system and the external environment. Our model comprises human cells and provides unique capabilities to replicate multiscale structural organization, biological phenotypes and dynamically regulated environmental homeostasis of the human ocular surface. Using this biomimetic system, we discovered new biological effects of blink-induced mechanical forces. Furthermore, we developed a specialized in vitro model of evaporative dry-eye disease for high-content drug screening. This work advances our ability to emulate how human physiological systems interface with the external world, and may contribute to the future development of novel screening platforms for biopharmaceutical and environmental applications.
논문정보
- Research article
- 2019년 08월 (BRIC 등록일 2019-08-23)
- 국외 연구진
- 바이오·의료융합 > 의료기기
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