한빛사논문
- 조회3,576
Hyeyoung Shin1,2,*, Christopher I. Moore1,2,3,*
1 Department of Neuroscience, Brown University, Providence, RI 02906, USA
2 Carney Institute for Brain Science, Brown University, Providence, RI 02906, USA
3 Lead Contact
*Corresponding author : Hyeyoung Shin, Christopher I. Moore
Abstract
Gamma oscillations (30–55 Hz) are hypothesized to temporally coordinate sensory encoding, enabling perception. However, fast spiking interneurons (FS), key gamma generators, can be highly sensory responsive, as is the gamma band local field potential (LFP). How can FS-mediated gamma act as an impartial temporal reference for sensory encoding, when the sensory drive itself presumably perturbs the pre-established rhythm? Combining tetrode recording in SI barrel cortex with controlled psychophysics, we found a unique FS subtype that was not sensory responsive and spiked regularly at gamma range intervals (gamma regular nonsensory FS [grnsFS]). Successful detection was predicted by a further increase in gamma regular spiking of grnsFS, persisting from before to after sensory onset. In contrast, broadband LFP power, including gamma, negatively predicted detection and did not cohere with gamma band spiking by grnsFS. These results suggest that a distinct FS subtype mediates perceptually relevant oscillations, independent of the LFP and sensory drive.
Keywords : primary somatosensory area of the neocortex; barrel cortex; whisker; detection; psychophysics; parvalbumin; synchrony; window of opportunity; inter-spike intervals; coefficient of variation
논문정보
- Research article
- 2019년 07월 (BRIC 등록일 2019-08-06)
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
