상위피인용논문
- 조회755
Yeon Seok Kimb,1, Nurul Hanun Ahmad Rastona,1, Man Bock Gua,*
a College of Life Sciences and Biotechnology, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-701, South Korea
b New Business Division SK Telecom, SK Telecom, 6, Hwangsaeul-ro 258 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 463-784, South Korea
1Equal contribution.
*Corresponding author : Man Bock Gu
Abstract
It has been more than two decades since aptamer and the systematic evolution of ligands by exponential enrichment (SELEX) method were discovered by Larry Gold and Andrew Ellington in 1990, respectively. Based on the various advantages of aptamers, they have become a potent rival of antibodies in therapeutics and bio-analysis. Especially, the recent advances in aptamer biosensor application are remarkable due to its intrinsic properties of aptamers as nucleic acids and target induced conformational changes, in addition to the introduction of graphene oxide-based easy and simple immobilization-free screening method even for dual aptamers. In addition, the incorporation of various nanomaterials such as metallic nanoparticles, carbon materials, and functional nanospheres in aptasensors has facilitated the improvement of analytical performance and commercial application of aptasensors. In this review, recent prominent reports on aptasensors utilizing nanomaterials were introduced to understand the principle of aptamer-based biosensors and provide an insight for new strategies of aptasensors and the application of various nanomaterials. The perspective on aptamer-based biosensors and diagnostics was also discussed in view of technology and market.
Keywords : Aptamers; Aptasensors; Nanomaterials
논문정보
- Review Paper
- 2016년 02월 (BRIC 등록일 2019-05-02)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
- 60회 이상 인용된 논문
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
