한빛사논문
- 조회1,009
Sungwoong Kim1,5, Shivem B. Shah2,5, Pamela L. Graney2,3,5 and Ankur Singh 2,3,4,*
1 Department of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
2 Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
3 Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
4 Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA.
5 These authors contributed equally: Sungwoong Kim, Shivem B. Shah, Pamela L.Graney
*Correspondence to Ankur Singh.
Abstract
Immunoengineering applies quantitative and materials-based approaches for the investigation of the immune system and for the development of therapeutic solutions for various diseases, such as infection, cancer, inflammatory diseases and age-related malfunctions. The design of immunomodulatory and cell therapies requires the precise understanding of immune cell formation and activation in primary, secondary and ectopic tertiary immune organs. However, the study of the immune system has long been limited to in vivo approaches, which often do not allow multidimensional control of intracellular and extracellular processes, and to 2D in vitro models, which lack physiological relevance. 3D models built with synthetic and natural materials enable the structural and functional recreation of immune tissues. These models are being explored for the investigation of immune function and dysfunction at the cell, tissue and organ levels. In this Review, we discuss 2D and 3D approaches for the engineering of primary, secondary and tertiary immune structures at multiple scales. We highlight important insights gained using these models and examine multiscale engineering strategies for the design and development of immunotherapies. Finally, dynamic 4D materials are investigated for their potential to provide stimuli-dependent and context-dependent scaffolds for the generation of immune organ models.
논문정보
- Review Paper
- 2019년 04월 (BRIC 등록일 2019-04-17)
- 국외 연구진
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