구.농수식품
- 조회915
Abstract
Jeong Wan Doa,1, Manoharan Saravananb,c,1, Sang-Eun Namb, Hyun-Jeong Limd, Jae-Sung Rheeb,c,e,*
a Aquaculture Research Division, National Institute of Fisheries Science, Busan, 46083, South Korea
b Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon, 22012, South Korea
c Research Institute of Basic Sciences, Incheon National University, Incheon, 22012, South Korea
d Aquaculture Industry Research Division, East Sea Fisheries Research Institute, Gangneung, 25435, South Korea
e Institute of Green Environmental Research Center, 169 Gaetbeol-ro, Yeonsugu, Incheon, 21999, South Korea
*Corresponding author : Jae-Sung Rhee
1These authors contributed equally to this work.
Abstract
Immunotoxic effects of manganese (Mn) were investigated in the blood of the economically important marine fish, red seabream (Pagrus major) and black rockfish (Sebastes schlegelii) when exposed to different concentrations of Mn (0, 0.5, 1, and 2 mg L−1) for 14 days. During exposure, the levels of alternative complement activity in both fish were significantly lowered at 2 mg L−1 of Mn of exposure. Lysozyme activity was significantly decreased in black rockfish in all concentrations of Mn after 14 days, while in red seabream, the decrease was significant with concentrations of 1 and 2 mg L−1 of Mn after 7 and 14 days of exposure. A significantly low level was observed only in the 2 mg L−1-exposed red seabream on day 14 of exposure. The concentrations of hemoglobin, red blood cells, white blood cells, and total serum proteins were significantly decreased in both fish under exposure to 1 and 2 mg L−1 of Mn, while cortisol, alanine transferase, aspartate transaminase, and alkaline phosphatase levels were significantly increased compared to the levels of control groups. No significant change was found in serum glucose and albumin except in red seabream exposed to 2 mg L−1 of Mn for 14 days. The responses of the antioxidant defense system were significantly induced in both fish after exposure to 1 and 2 mg L−1 of Mn on day 7 and 14 of exposure. Taken together, alterations of these parameters suggest the immunotoxicity of waterborne Mn produced by the modulation of hematological components and the induction of oxidative stress in the blood of these marine fish.
Keywords : Manganese; Red seabream; Black rockfish; Immunity; Hematology; Oxidative stress
논문정보
- Research article
- 2019년 03월 (BRIC 등록일 2019-04-22)
- 국내 연구진
- 생명과학 > 수산학
- 구・농수식품
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