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Cell Host Microbe, Published: March 21, 2019 | DOI:https://doi.org/10.1016/j.chom.2019.02.001 Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear

Jinsei Jung,^1,2,7 Jee Eun Yoo,^1,2,7 Young Ho Choe,^3,4 Sang Chul Park,¹ Hyun Jae Lee,^1,2 Hack June Lee,^1,2 Byunghwa Noh,^1,2 Sung Huhn Kim,^1,2 Gyeong-Yi Kang,^3,4 Kang-Mu Lee,⁵ Sang Sun Yoon,^4,5 Dong Su Jang,⁶ Joo-Heon Yoon,^1,2 Young-Min Hyun,^3,4,* and Jae Young Choi^1,2,8,*

¹ Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea
² Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea
³ Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
⁴ Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
⁵ Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, South Korea
⁶ Department of Sculpture, Hongik University, Seoul, South Korea
⁷ These authors contributed equally
⁸ Lead Contact

^*Corresponding author

Abstract

In the inner ear, endolymph fluid surrounds the organ of Corti, which is important for auditory function; notably, even slight environmental changes mediated by trauma or infection can have significant consequences. However, it is unclear how the immune response is modulated in these tissues. Here, we report the local immune surveillance role of cleaved cochlin LCCL (Limulus factor C, Cochlin, and Lgl1) during Pseudomonas aeruginosa infection in the cochlea. Upon infection, the LCCL domain is cleaved from cochlin and secreted into the perilymph. This cleaved fragment sequesters infiltrating bacteria in the scala tympani and subsequently recruits resident immune cells to eliminate the bacteria. Importantly, hearing loss in a cochlin knockout mouse model is remedied by treatment with a cochlin LCCL peptide. These findings suggest cleaved cochlin LCCL constitutes a critical factor in innate immunity and auditory function and may be a potential therapeutic target to treat chronic otitis media-induced hearing loss.

논문정보

형식Research article
게재일2019년 03월 (BRIC 등록일 2019-03-28)
연구진국내 연구진
분야 의약학 > 응용의학

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