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Leukemia, Published: 23 January 2019 | https://doi.org/10.1038/s41375-018-0309-4 Characteristic gene alterations in primary gastrointestinal T- and NK-cell lymphomas

Gunho Lee^1,2, Hyang Joo Ryu³, Ji Woon Choi⁴, Hyundeok Kang^1,5, Woo Ick Yang³, In Seok Yang¹, Mi-kyoung Seo^1,5, Sangwoo Kim^1,5, Sun Och Yoon³

¹ Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea
² Graduate Program for Nanomedical Science, Yonsei University, Seoul, Republic of Korea
³ Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea
⁴ Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
⁵ Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea

These authors contributed equally: Gunho Lee, Hyang Joo Ryu
These authors jointly supervised this work: Sangwoo Kim, Sun Och Yoon

Abstract

To the Editor:
Systemic T and natural killer (NK) cell lymphomas (systemic TNKLs) are malignancies stemming from lymphocytes of T- and NK-cell lineage that preferentially occur in East Asians. Despite an aggressive nature and poor patient outcomes, their rarity and histological heterogeneity have limited the development of effective therapeutic options. Several subtypes have been described for TNKLs according to their cellular origin and site of occurrence: these include angioimmunoblastic T-cell lymphoma (lymph nodes) and extranodal NK/T-cell lymphoma (ENKTL) (nasal/paranasal sites of the head/neck). Some TNKLs, such as enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), are frequently found along the gastrointestinal (GI) tract and are known to be more aggressive, with patients experiencing bleak clinical outcomes [1]. While this might indicate a site-specific preference in the formation and progression of TNKLs, the molecular biology underlying such preference has not been fully elucidated. In this study, we sought to investigate genetic alterations in primary GI-TNKLs in a comparative manner to characterize the molecular features thereof and to gain insights into the site-specific tumorigenesis of TNKLs.

논문정보

형식Research article
게재일2019년 01월 (BRIC 등록일 2019-02-01)
연구진국내 연구진
분야 의약학 > 응용의학

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